• Front of Tranquilene bottle

Tranquilene Total Calm®

Natural Stress and Anxiety Supplement

A comprehensive natural anti-anxiety supplement designed to correct stress-causing nutritional imbalances over time while providing immediate herbal calming.

One-Time Order Options
Ships within 24 hours


Fights Anxiety, Stress and Panic

Supports Serotonin and GABA

Promotes Emotional Balance

Encourages Positive Mood

No: Soy Gluten GMOs
Results may vary.


  • Your Peace of Mind Shield

    With both short and long-term active ingredients, Tranquilene® is your daily mood shield. When we ask customers how it works for them, most say something like: “It makes be better able to handle things that would normally set me off.”

  • Immediate Panic and Anxiety Relief System

    On the front lines of Tranquilene’s fight against anxiety are the powerful herbal calming agents Ashwagandha, Brahmi and Passionflower. Passion Flower has a mild but fast-acting calming effect. Ashwagandha and Brahmi (or Bacopa Monnieri) come from the Indian medical tradition of Ayurveda and have been used for centuries to treat anxiety, depression and panic attacks, while sharpening cognitive performance.

  • Long-Term Mood Support System

    The key to why Tranquilene® grows even more effective over time is the combination of L-Theanine, Vitamin B Complex, Vitamin D and L-Tryptophan. These important compounds work with your brain to balance your levels of Serotonin and GABA, the two Neurotransmitters that have the greatest impact on mood.

  • Natural Isn’t a Word, It’s a Way of Life

    Tranquilene® is not a harsh pharmaceutical medication. While our ingredients are pharmaceutical grade in quality, they are derived from completely natural sources. We use no artificial fillers, no industrial solvents on our machines and no substitute or low quality ingredients.

  • Unsurpassed Value and Quality

    If you were to buy all 15 ingredients in Tranquilene® separately, the cost would be well over $100 for just a single month’s supply. We are committed to attacking stress and anxiety from as many directions as possible, at a fair price. Not a milligram of space is wasted in our capsules.

  • Easy Everyday Mood Support

    For about a dollar a day you can hop on our Tranquilene® AutoShip Program and never miss a dose. We’ll send you a one month supply each month until you decide to cancel, and we stand by our “no-drama” cancellations policy. For best results, we recommend taking Tranquilene® for at least four months.


We at Tranquility Labs® want to share with you a number of exciting advancements that have been made in the science of fighting anxiety. In recent years, a handful of enzymes, amino acids, herbal extracts, vitamins and minerals have been identified as effective in eliminating anxiety in both men and women. The powerful result when these vitamins, minerals, amino acids, enzymes and herbs are combined has to be seen to believed.Tranquilene® works by optimizing the effects of these natural compounds and other key ingredients in a powerful but safe and non-addictive formula. Here are the main components:

L–theanine, an amino acid found in green tea, produces a pronounced feeling of tranquility in as little as 15 minutes. L–theanine increases the activity of GABA, a neurotransmitter (natural messenger in the brain) that promotes relaxation and reduces anxiety. L–theanine also stimulates the release of dopamine, a neurotransmitter responsible for confidence and a sense of well–being.
Gama Aminobutyric-acid (GABA) is an amino acid and the main inhibitory (calming) neurotransmitter in the brain. GABA is a natural calming agent that prevents excessive muscle tension and helps our bodies make endorphins, chemicals that make us feel happy. Deficiencies of GABA in the brain have been linked to insomnia and feeling anxious, stressed, tense and depressed.
Ashwagandha has been used in the Indian tradition of Ayurveda in health tonics and calming serums. Recent studies demonstrate that Ashwagandha is an antioxidant that can treat anxiety, depression, panic attacks and phobia.
Brahmi (Bacopa Monnieri)
Often used by Ayurvedic healers to accompany Ashwagandha, Brahmi (a.k.a. Bacopa Monnieri) is a mild sedative that supports the body during periods of emotional stress. Traditionally, Brahmi is prescribed to promote healthy cognitive functions, including focus, concentration, mental endurance and memory. Modern studies have found that Brahmi’s anti-anxiety properties were as potent as those of Lorazepam, with none of the side effects.
Tryptophan is the number 1 supplement purchased to fight stress and anxiety. It is an essential amino acid that the body converts into 5-HTP (5-hydroxy-tryptophan), and then to Serotonin. Serotonin is involved in mood, appetite, sleep and impulse control. Once the Serotonin neurotransmitter is made, the brain is able to convert it into melatonin, the sleep-inducing hormone, at night.
Passion Flower
For centuries, herbal medicine practitioners have used Passion Flower as a natural remedy for anxiety, stress and insomnia. Modern clinical studies shows that Passion Flower extract significantly lowers anxiety levels and promotes a more tranquil frame of mind. Studies also indicate that Passion Flower can reduce anxiety-related discomfort caused by withdrawal from opiates and other drugs.
Magnesium deficiency is one of the leading causes of anxiety and insomnia and the western diet tends to be lacking in this critical element. Research now shows that as magnesium levels drop, symptoms of anxiety and depression can increase.
Niacinamide, a type of vitamin B3, works with the body to convert Tryptophan into 5-HTP, which can then be converted into Serotonin. Without B3, Tryptophan–5HTP conversion cannot take place. Common symptoms of B3 deficiency include irritability, poor concentration, anxiety, fatigue, restlessness, apathy, and depression. We chose niacinamide over niacin to prevent the side effect of red flushing that often occurs when taking raw niacin.
B Complex
Getting enough of the many forms of Vitamin B is essential to maintaining proper brain function. Vitamin B is involved in the metabolism, as well as the production of Serotonin. Low levels of vitamin B have been linked to, anxiety, restlessness, fatigue, irritability, and emotional instability. Tranquilene® contains vitamins B1, B3, B5, B6 and B12.
Vitamin D3
Vitamin D is widely popularly for its importance in preventing heart conditions, balancing blood pressure, and maintaining strong, healthy bones. Research now shows us that Vitamin D3 is also involved in the process of converting Tryptophan – a key ingredient in Tranquilene® – into Serotonin, a neurotransmitter that helps regulate mood. Vitamin D3 helps this process to occur in your brain, where it should, instead of in your gut, where the Serotonin might not be properly utilized.

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Brahmi (Bacopa Monnieri)
Brahmi (Bacopa)
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Passion Flower
Passion Flower
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B Complex
B Complex
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Vitamin D3
Vitamin D3
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How it Works

  • Overview
  • Is it Right for Me?
  • Safety Information
  • Frequently asked questions?
Tranquilene® works daily to keep you calmer and nutritionally equipped to handle the stresses of life.
Tranquilene’s unique formula brings together the best of western science with some of the Eastern world’s most effective herbal mood-balancing remedies for a safe and effective natural anti-anxiety formula. While our calming botanical blend works to quickly bring down that panicky feeling, our scientifically-formulated Serotonin and GABA support system works with your body to build long-term mood support. And unlike many of the hard drugs pharmaceutical companies push, Tranquilene® is all-natural and non habit-forming.

Is Tranquilene® for me?

  • Do you experience excessive ongoing worry or tension?
  • Do you often feel restless or edgy?
  • Are you easily startled or made to worry?
  • Do the stresses of every day life often overwhelm you?
  • Do you find it difficult to face social situations?
  • Do you experience muscle tension, headaches and/or difficulty concentrating?
  • Have you suffered from a panic attack in the past six months?

If you answered yes to any of these questions, you may suffer from anxiety, social anxiety, stress or panic attacks. Tranquilene® is an all-natural supplement designed to provide FAST anxiety relief, long-term mood support and everyday stress control. Our clinically proven ingredients combine the best in western science with the most effective in eastern herbal medicine, bringing you the safest, most potent formula on the market.

Safety Information
Tranquilene® is safe, natural and usually well tolerated by the body. Most people who take Tranquilene® do not experience side effects. When side effects do occur, they tend to be mild and short-lasting.You can safely take Tranquilene® with all nutritional supplements and most prescription medications.Please consult a physician before taking Tranquilene® if you are pregnant or nursing.Recommended dosage is two capsules taken with water, either both in the morning, or one in the morning and one in the afternoon – as you see fit. It is not recommended that you exceed three capsules at a time or four in one day. Exceeding the maximum dosage is not dangerous, though it may lead to excessive drowsiness.When taken as directed, Tranquilene® is safe and poses no short-term or long-term health risks.
Drug Interactions
Please talk to your doctor before taking Tranquilene® with blood thinners, muscle relaxants, other sleep or anxiety medicines, pain medicines, seizure medicines, or other medicines that cause drowsiness. Tranquilene® may increase the sedative effects of these drugs.Do not consume excessive quantities of alcohol while taking Tranquilene®. Tranquilene® may increase the sedative effects of alcohol.Do not take Tranquilene® if you are currently taking an MAOI or have taken an MAOI within the past two weeks.

Possible Side Effects
While most people taking Tranquilene® experience NO side effects, possible side effects can include:
  • drowsiness
  • fatigue
  • stomach upset
  • headache
  • morning grogginess (if taken before bed)
  • increased effects of sedative drugs
  • lowering of blood pressure

Feel free to contact Tranquilene® Customer Support if you have any questions or concerns.

Where is Tranquilene® manufactured?
Tranquilene® is made in the USA in a facility that meets FDA’s guidelines and was awarded the NSF seal for Good Manufacturing Practices (GMP). Sadly, many stress and anxiety products available online are made in China. China currently has a bad track record with product contamination after lead was found in numerous products. We are proud to manufacture Tranquilene® in the US.

Do you only offer monthly auto-ship subscriptions?
We offer several options for ordering, which you can find at our Order Options page. The monthly auto-ship program is the least expensive option and you can cancel at any time.

How do I cancel my auto ship?
You can cancel at any time by emailing Your cancellation will be processed within 48 hours.

How long will it take to reach me?
All orders are shipped USPS First Class with tracking. Orders are shipped within one business day and, for orders within the US, it should reach you within a week.

How long does Tranquilene® take to work?
Our formula works in two parts: 1) to bring down current anxious feelings quickly and 2) to restore balance to your body’s natural stress fighting systems. The immediate effects can take edge off in as few as 20 to 30 minutes. The long term balance takes consistency, however, which is why we recommend taking Tranquilene® for at least three or four months.

Do you offer free samples?
We are confident Tranquilene® will work for you and want you to try the first bottle for a full month, risk free with our 60-day, money-back guarantee.

Is it shipped discreetly?
Yes, it comes in a plain brown package that simply bears our name “Tranquility Labs® LLC”

How can I check the status of my order?
You can feel free to ask us about the status of your order at, or use the tracking number supplied in your e-mailed receipt to keep track of your shipment’s location.

Can I take Tranquilene® with my medication?
Tranquilene® is a natural formula and safe to take with most medications. However, we do urge you to check with a doctor or pharmacist for any possible interactions if you are currently on any medications. For more information, visit our Safety Information page.

What is the recommended dosage of Tranquilene®?
Recommended dosage is two capsules taken with water, either both in the morning, or one in the morning and one in the afternoon – as you see fit. For maximum effectiveness, we recommend taking it 20 to 30 minutes before food. It is not recommended that you exceed three capsules at a time or four in one day. Exceeding the maximum dosage is not dangerous, though it may lead to excessive drowsiness.

How do I order Tranquilene®?
You can order online at All you need is an address and your credit card.

Why should I also take SleepFast?
Tranquilene® is meant as a daytime formula, which means we left out anything that might make a person tired. SleepFast was designed to complement Tranquilene® by not only helping you get to sleep, but helping your mind achieve deeper, more restful sleep.

What forms of payment do you accept?
We accept Visa, Master Card, American Express and Discover. We apologize, but we do not accept cash, checks, money orders or PayPal.

How can I be sure my information is secure?
Tranquility Labs® LLC only uses encrypted, PCI-compliant methods for storing and transferring customer data. Customer security is a top priority.

What is your guarantee?
Tranquilene® orders come with a 60 day guarantee. If you are unsatisfied for any reason you may return the product within 60 days for a full refund of the purchase price.


Supplement Facts Label
Hard facts about the nutritional value.
Download our Free e-Book
The Natural Guide to Anxiety Free Living
Clinical Research
Learn the science behind


  • “It keeps the stress from affecting my work.”
    I found your product by accident while browsing the web, learning about what causes anxiety and what prevents it. I was impressed by the list of ingredients so I gave it a try. I couldn’t believe the difference after just two months! My job in New York’s financial sector can be extremely stressful and Tranquilene is just what I need to keep the nerves from getting to me.
    Peter J., New York, NY

    “Thank you so much for this product, it’s a life saver!”
    For the past 3 or 4 yrs, I was going thru alot of personal things. Working a full time job and being available as much as I can for my adult children. I was getting more and more panic/anxiety attacks and nite after nite of sleeplessness. My mind wouldn’t stop. Fast forward to last summer, when I made the decision to move out, the panics /anxiety subsided a little, but the sleeplessness didn’t. I was told to go on an anti depressant, but didn’t want any of the side affects. Thru my own research I came across Tranquilene. I read the testimonials and thought I would give it a try, as I just couldn’t sleep and the panic attacks were heavy on my chest at times. I received the product within 2 days of ordering. Within about 5 days I started feeling such a difference! The anxiety/panic attacks have totally disappeared, and with taking Sleep Fast at nite, I finally get a full nites sleep. I have taken the product 3 months and I won’t go without it… I do find that if I don’t take the morning dose, within an hour of waking the heaviness starts. The product is amazing, and obviously whatever my body is missing this product helps balance things (I also have Celiac disease). I am on an automatic shipment which is perfect so I don’t run out. Thank you so much for this product, it’s a life saver!†
    Kim B., Mt Joy, PA


    “I like Tranquilene!”
    It doesn’t make me feel numb, gives me sense of calm and helps me keep a handle on my stress. I like that they send me emails with tips about living a healthy life. Latest email I read was about exercise. I have started this part by doing Zumba and taking walks more frequently with my dog and kids. They help me feel better about myself and experiencing life to the fullest! I am very happy with this product.
    Myranda L., Castle Rock, WA

  • “Finally feeling confident.”
    Tranquilene is my weapon against anxiety. Since I’ve been taking it I feel like I have so much less to worry about.
    Otis, Casper, WY
    “All along it was just an imbalance.”
    I thought for years that something was wrong with my genes, or wrong with my mind or, well, wrong with ME. But when I started doing research about what makes people anxious I suspected it may just be a chemical imbalance. Your product had the best combination of ingredients I could find and now, after just a few months of taking it, I realized I was right.
    Stephani B., Salem OR
    “What a difference.”
    Before Tranquilene I was always just one bad day away from an anxiety attack. But I don’t have to worry about those anymore. Thanks so much and keep up the great work.
    Farah, F, Derby, CT
  • “Great product!!”
    I am sure you’ve heard this a zillion times, but thanks for creating a great product. I have a lot of stress and anxiety but I didn’t believe my therapist when she told me I actually had a disorder and had to go on meds. I had only felt so anxious for a few years so I figured it couldn’t just be who I am. Anyways, my therapist said I should take supplements to build up GABA and Serotonin and I was SO surprised that those are exactly the things Tranquilene focuses on. Now I’m taking a break from therapy.
    Lana J., Salt Lake City, UT
    “So THIS is living!”
    I used to be so anxious. Anxious to go to the bank, anxious to meet up with friends, anxious to go for a checkup. It felt like something was holding me back and god forbid ANYTHING in my life went badly. I would shut myself in. I went through a lot of therapy about my phobias, but it didn’t relieve that gut–wrenching anxious feeling I always got. And then I found Tranquilene. My family can’t believe how much more “chilled out” (as my nephew says) I’ve become.
    Elizabeth R., Loveland, OH
    “Helps me not worry about the little things”
    Growing up, i was always a little bit more panicky then others. Im such a rule follower and if plans do not go according to the itinerary I would feel like everything is crashing down. I grew out of that as i was growing up but I started worrying about all kinds of little things. What meals would I eat this week, how much am I spending at Starbucks, is my house clean enough for the bf… I am always going to think about this stuff but I certainly don’t need to be panicking about it. Tranquilene took all the stuff I worry about and made it just the stuff I think about. No racing heartbeat about it!
    Pamela K, Kittery ME
Results may vary.

Tranquilene Total Calm®

Natural Stress and Anxiety Supplement

A comprehensive natural anti-anxiety supplement designed to correct stress-causing nutritional imbalances over time while providing immediate herbal calming.

One-Time Order Options
Ships within 24 hours